Abstract: Fengxi river gold mine in Longhui County of Hunan Province is located in the central segment of Xuefeng arcuate tectonic belt within Jiangnan Orogenic Belt, which had undergone multiple phases of tectonic-magmatic activity and regional metamorphism, making it a significant polymetallic gold metallogenic prospecting area in South China. Based on comprehensive regional geological data and exploration results, and combined with geophysical, geochemical, trenching, and drilling data, the authors in this research systematically investigated the metallogenic geological conditions and prospecting indicators of Fengxi river gold mine. The results showed that 7 ore veins and mineralized zones had been exposed at Fengxi river gold mine, and the mineralization was mainly hosted in the contact zones between the shallow-metamorphosed clastic rocks of Qingbaikou System and the volcanic-sedimentary rocks of Nanhua System, as well as interlayer fault zones. The wall rock alteration featured moderate to strong silicification and pyritization. Seven Au anomalies and six As anomalies were delineated, forming four combined anomalies. Additionally, a comprehensive prospecting indicator system was established, including stratigraphy, structure, mineralogy, heavy minerals, geophysical anomaly, geochemical anomaly, and old workings. The stratigraphic contact between Qingbaikou System and Nanhua System, high polarizability-medium-low resistivity geophysical anomaly, Au-As association geochemical anomaly, strong silicification-pyritization-arsenopyritization were identified as core prospecting markers. The research findings could provide basis for subsequent prospecting deployments and regional exploration of similar gold deposits in this area.