Abstract: The resource exploration in sedimentary basins was mainly focused on large-scale basins in China, but numerous and widely distributed small-medium basins also contain significant multi-resource potential. Recent exploration practice has revealed that small-medium basins have symbiotic accumulation characteristics, showing the significant value of co-exploration. In order to address key challenges including the unclear spatial distribution patterns of multi-type energy resources and the inadequacy of single-resource exploration paradigms to meet comprehensive evaluation needs, the authors analyzed the multiple-resource co-occurrence mechanisms of oil and gas, helium and hydrogen resources in small-medium basins of North China, and revealed the strategic guiding role of Trinity model in publicly funded geological surveys. Besides, the efficiency of selecting preferred targets was improved to achieve the strategy value of commercial exploration, and the multidimensional collaborative development pathways of space-engineering-policy were put forward. It is verified that this pathway has guiding significance for releasing reliable strategic-potential resources in small-medium basins.