Abstract: To achieve geological disaster risk assessment for a single landslide with uncertain locations and probabilities of instability, the authors in this research chose a typical landslide in the northern foothills of Dabie Mountains. First, four working conditions were set, and the most unfavorable potential sliding surface was identified using GEO-SLOPE software, with the failure probability being simulated based on the Monte Carlo principle. Subsequently, the maximum landslide run-out distance was calculated using an empirical formula. Combined with field survey statistics, the hazard-bearing body was delineated for different working conditions. Finally, on the basis of analyzing the vulnerability and monetary value of each element, the property risk and population risk under all working conditions were quantified using a risk calculation model. The results demonstrate that under working condition 4 (which represents a once-in-a-century rainfall event with a fully saturated landslide body), the number of exposed individuals was 5 and the potential economic loss was approximately 592.7 thousand CNY. Compared to traditional methods relying solely on statistical data, the proposed approach yields more refined and accurate results, providing valuable references for targeted risk mitigation strategies against geological hazards.