Abstract: Xiaoshan area in Henan Province is located in the gold-molybdenum-bauxite lead-zinc polymetallic mineralization belt in the western Henan, with superior geological conditions for mineralization. However, due to the severe Quaternary system and vegetation coverage, it is difficult to carry out traditional geological mapping and geochemical exploration work. By using comprehensive geophysical prospecting method of high-precision magnetic method, induced polarization midale gradient and induced polarization sounding, and combined with drilling verification, the authors identified the distribution of concealed rock masses, strata and structures in Xiaomeihe area of Xiaoshan, and delineated favorable target areas for polymetallic prospecting. The results show that the contact zone between Yanshanian granites and Taihua Group is a favorable location for polymetallic mineralization. The combination of high magnetic anomalies and high resistance and high polarization is an important indicator for identifying concealed granites. The electrical property mutation zone (high resistance-low resistance transition zone) between granites and andesites may correspond to hydrothermal alteration or polymetallic mineralized bodies. The high polarization anomaly zone is closely related to polymetallic mineralization. The comprehensive geophysical prospecting method provides efficient and low-cost technical means for gold exploration in Xiaoshan area. This research could provide references for future mineral exploration in this area.