Abstract: National Highway 219 starts from Yecheng County of Kashgar Area in Xinjiang in the north and ends at Lazi County of Shigatse City in Tibet in the south. The terrain conditions along National Highway 219 are complex, and the climate is harsh, with sparse population. The field survey is difficult to carry out and the remote sensing technology is one of the indispensable means for studying geohazard potentials in this area. The remote sensing interpretation signs of collapse-landslide geohazard potentials are established according to the hue, shape, texture and shadow characteristics of remote sensing images. A total of 126 collapse and landslide geohazard potentials were identified along National Highway 219, including 39 rock landslide potentials, 6 soil landslide potentials and 81 rock collapse potentials. Based on the characteristics of slope angle, rock (soil) type, geological structure and slope structure, the authors analyzed the influencing factors and spatial distribution of couapse and landslide geohazard potentials to divide four concentrated distribution areas, namely Saga concentrated distribution area (I), Suode-Tangre concentrated distribution area (II), Risong-Duoma concentrated distribution area (III) and West Kunlun concentrated distribution area (IV). The collapse-landslide geohazard potentials on the upper position of the slope have the characteristics of high-locality chain disasters, and these geohazard potentials have characteristics of strong concealment, long runout and strong destructiveness, and we should pay more attention to the study of such disasters. This research could provide some references for disaster prevention, mitigation and important engineering construction planning along National Highway 219.