Abstract: The big rare metal deposits, such as Chuanziyuan (Li ore and Nb-Ta ore), Liren (Nb-Ta ore) and Huxingshan (W ore and Be ore), are distributed in Mufushan area of Northeast Hunan, and this area is an important pegmatite-type rare metal deposits ore-concentrated area. According to the chronological and petrogeochemical characteristics of granite and pegmatite in Mufushan area, the authors discussed the relationship between Yanshanian magmatic activity and rare metal mineralization. The results show that the magmatic activity lasted from Jurassic (154 Ma) to Cretaceous (92 Ma), and complex granite bodies and pegmatite veins have been formed, with lithologic zonation characteristics in pegmatite veins. The ore-forming age of pegmatite (130~127 Ma) is similar to the rock-forming age of mica monzonitic granite (137~129 Ma), and the mineralization of pegmatite is closely related to the high differentiation evolution of magma. The lithologic zonation characteristics in pegmatite veins are affected by the ore-forming fluid temperature, and the temperature in pegmatite decreased with the increase of distance from the rock body. Therefore, the circular distribution pattern has been formed form the rook body, with a sequence order of the pegmatite-type Bb ore belt lin the rock body→the pegmatite-type Nb-Ta ore belt (0~3 km)→the pegmatite-type Li-Nb-Ta ore belt (3~5 km)→the quartz vein type Be ore belt.