Abstract: Well Xinwudi1 is located in Wushixi tectonic belt on the northwestern margin of Tarim Basin. The fault was well developed, and the reference materials from adjacent wells were lacking. The regional geological survey is not thorough and the formation is extremely complex, with leakage, fragmentation and diameter reduction, which brings great challenges to drilling construction. In order to solve the problems, such as the lack of basis for well structure design, the extremely complex formation and the difficulty of handling accidents, several key technologies such as super-pilot open hole drilling, deep overburden plugging, serious in-well accident handling and complex formation drilling fluid retaining wall have been applied. These technologies have helped reduce the construction cost. The drilling technology system has been developed and is suitable for the small-diameter oil and gas survey well with complex strata in the southwestern and southeastern depression of Tarim Basin. It will provide reference for similar drilling construction in this area in the future.