Abstract: With the rapid development of new energy automobile industry and the breakthroughs of controlled fusion technology, the strategic position of lithium continues to improve. Although domestic lithium reserves in salt lake deposits are huge in China, the development and utilization technology still needs to be improved. There have been great breakthroughs in prospecting for hard rock type lithium in Jiajika of Sichuan, but the general level of prospecting is still very low, especially that most drilling depths are less than 300 m. The external dependence of lithium in China is up to 74%. So it is extremely urgent to carry out deep lithium energy metal exploration in the known lithium reservoirs. The important trends of deep lithium ore deposits exploration are studying metallogenic regularity of lithium energy metal, lithium isotope, geogas prospecting, deep-penetrating geochemical prospecting, potential evaluation techniques and prospecting methods. By summarizing the general features of different types, metallogenic condition and burial depth of lithium ores including Sichuan Jiajika, Xinjiang Kalu’an, Sichuan Huangjinkou and Guizhou Dazhuyuan, the authors generalized the metallogenic regularity and distribution of lithium resources, and indicated prospecting direction as follows: prospecting deep lithium deposits in Jijika and Keeryin of Sichuan according to the model of "five floors + basement", predicting concealed rocks in Kalu’an of Xingjiang, prospecting the liquid lithium resource by co-exploration of potash and lithium in Huangjinkou of Sichuan, and prospecting the sediment-type lithium resource in Chongqing and Guizhou.